RESEARCH

Publications

  • A common longitudinal intensive care unit data Format (CLIF) for critical illness research, 2025
    SpringerNature

  • Age and Saving Lives in Crisis Standards of Care: A Multicenter Cohort Study of Triage Score Prognostic Accuracy, 2025
    PubMed Central

  • Characterizing variation in documented delivery of spontaneous awakening trials across five health systems, 2025
    American Thoracic Society

  • Foundation models for electronic health records: representation dynamics and transferability, 2025
    arXiv

  • Patient preferred language and deep sedation during invasive mechanical ventilation: A multicenter retrospective cohort study, 2025
    American Thoracic Society

  • Speaking common longitudinal ICU data format (CLIF): A large language model for critical care phenotyping, 2025
    American Thoracic Society

  • The effect of the optional lactate criterion for organ dysfunction on CDC adult sepsis event incidence and mortality, 2025
    American Thoracic Society

  • The epidemiology of intensive care unit readmissions across 8 academic medical centers, 2025
    American Thoracic Society

  • The epidemiology of intensive care unit readmissions across ten health systems, 2025
    medRxiv

  • A Common Longitudinal Intensive Care Unit data Format (CLIF) to enable multi-institutional federated critical illness research, 2024
    PubMed Central

  • Variation in setting low tidal volume ventilation on day 1 of mechanical ventilation by hospital, 2024
    American Thoracic Society

Conferences

American Thoracic Society 2025 Conference

American Thoracic Society (ATS)
2025


Committee members present various CLIF studies:

  • Electronic health record signatures of spontaneous awakening trials: A multi-center analysis of sedation cessation patterns in mechanically ventilated patients, 2025
    American Thoracic Society

  • Multi-center evaluation of prone positioning practices for moderate and severe hypoxemic respiratory failure, 2025
    American Thoracic Society

  • The association of sex and height with low-tidal volume ventilation in a multi-center cohort of critically ill adults, 2025
    American Thoracic Society

  • The common longitudinal intensive care unit (CLIF) respiratory support waterfall: A novel method for analyzing ventilator mode patterns in critical care, 2025
    American Thoracic Society
ATS 2024 Conference

American Thoracic Society (ATS)
2024


Various CLIF studies presented by members:

  • Advancing multi-center clinical research in critically ill patients through the development of a common longitudinal ICU format (CLIF), 2024
    American Thoracic Society

  • Identifying windows of opportunity for early mobilization of mechanically ventilated patients: Multi-center comparative analysis of clinical trial and consensus guideline eligibility criteria, 2025
    American Thoracic Society

  • Variation in setting low tidal volume ventilation on day 1 of mechanical ventilation by hospital, 2024
    American Thoracic Society

AMIA 2024 Conference

American Medical Informatics Association (AMIA)
2024 Informatics Summit


Kaveri Chhikara, presents the CLIF at the AMIA Summit, touching on the standardized data format created to address challenges in using ICU electronic health record data for research.

Ongoing Projects

The CLIF consortium is a network of NIH funded investigators.

Principal Investigators (PIs) in the consortium are supported by a wide range of NIH grants that use big data and advanced ML techniques to answer open scientific questions related to critical illness. Each of these projects would be better with CLIF rather than done in silos.

Improving the efficiency and equity of critical care allocation during a crisis with place-based disadvantage indices

  • CLIF Project Description: Creating a life support allocation triage score for crisis standards of care
  • Grant: R01 LM014263
  • PI: William Parker, University of Chicago

Identifying Areas to Improve ICU Outcomes through Provider Variation

  • CLIF Project Description: Studying hospital variation in low-tidal volume ventilation across hospital systems
  • Grant: K23 HL166783
  • PI: Nicholas Ingraham, University of Minnesota

Identification of Precision Sepsis Subphenotypes Using Vital Sign Trajectories

  • CLIF Project Description: Validating the association of temperature trajectories and ICU mortality across hospital systems
  • Grant: K23 GM144867
  • PI: Sivasubramanium Bhavani, Emory University

Sustainable Implementation of Prone Positioning for the Acute Respiratory Distress Syndrome

  • CLIF Project Description: Studying the association between proning practice patterns and ARDS survival
  • Grant: K23 HL169743
  • PI: Chad Hochberg, John Hopkins University

Early Mobilization: Operationalizing Big Data & Implementation Science to Lead Expansion to ICUs (E-MOBILE-ICU)

  • CLIF Project Description: Identifying critically ill patients who are eligible for mobilization using the electronic healthcare record
  • Grant: K23 HL148387
  • PI: Bhakti Patel, University of Chicago

Machine learning to predict cure in severe pneumonia episodes

  • CLIF Project Description: Prediction of severe pneumonia using machine learning
  • Grant: K23HL169815
  • PI: Catherine Gao, Northwestern University

SPOT-IT: Sepsis Prediction in Oncology Through Implementation Science and Technology

  • CLIF Project Description: Develop an oncology-specific sepsis prediction model using EHR data and human-centered design
  • Grant: K08CA270383
  • PI: Patrick Lyons, Oregon Health and Science University